Reflections on the Nature and Future of Systematic Review in Healthcare. by Barry Robson PhD DSc (Rough Draft, Version 1.0, Feb 22 2015) 1. Systematic Review A systematic review (SR) is “a high-level overview of primary research on a particular research question that tries to identify, select, synthesize and appraise all high quality research evidence relevant to that question in order to answer it” . The systematic review is an approach to decision making to healthcare that is promoted by the Cochrane Collaboration . The Cochrane Collaboration prepares, maintains and promotes systematic reviews to inform healthcare decisions as “Cochrane Reviews”. The approach is based upon the views expressed by Archie Cochrane  as to what strategy should be applied in healthcare in order to best benefit patients, and not least to avoid harming them. The general approach is consistent with that David Sackett  and Muir Gray  who framed, implemented, and refined Cochrane’s proposed methods as “Evidence Based Medicine”….